I am pretty sure that this review paper was written after the controversy about parabens had become public, because many of the criticisms of the earlier paper are addressed.
It emphasises that any personal care product containing parabens is equally risky, and that the particular kind of product is irrelevant. This is certainly true – if parabens do indeed have the ability to cause breast cancer then they should not be used in any personal care product. The reporting that concentrated on underarm antiperspirants was in this sense very misleading from whatever way you chose to look at it. It also gave industry critics a great stick with which to beat the original paper.
The argument is about parabens and nobody has ever disputed that they are widely used in cosmetics, although they are used at low levels. As a cosmetic formulator I can tell you that it is very rare that you need more than about 0.4% of parabens to adequately preserve a formulation. The legal limit is 0.8%. In any case they are usually used in combination with other preservatives in which case the levels are even lower. Nobody wants to use any more than they have to. Parabens are cost effective but they are still an expense.
In what looks suspiciously like cosmetic industry bashing for the sake of it, Dr Darbre has found some published data which analyses the paraben level of some marketed products and finds that some exceed the legal limit, and some that contain parabens that aren’t labelled as such.
I think that this point is wholly irrelevant to the question of whether or not parabens are safe. I doubt very much that the data showing levels of parabens higher than legal limits are accurate. Measuring the levels of parabens in samples accurately is not easy. A glance at Dr Darbre’s original paper will show that she herself isn’t very good at it. Remember that she detected parabens in her blank control samples where presumably there weren’t any either.
I have seen enough inaccurate chemical analyses in my career to have good grounds for scepticism about these figures.
But I don’t think anything is achieved by trying to knock the cosmetic industry’s compliance with legislation. It is a big and diverse industry and while there are no doubt a few rogues about if you look long and hard enough, the big companies all work to very high standards in their plants. They follow the rules. The debate should be about whether the regulations are protecting consumers. And to answer that, we need to know whether parabens actually pose a risk or not. If the link with breast cancer turns out to be true, then we shouldn’t be using them at all at any level.
Parabens have been used so long that when they were approved the requirements to prove their safety were much lower, and the gaps have never been filled in
Parabens were not covered by any legislation in Europe until 1976. In that year they were approved for use and the issue had never been looked at again since that time. Parabens had however been looked at by food regulators in the late nineties. This highlighted that there was little data available on whether they might cause cancer and none at all on effects on reproduction. So regulations have been set without any information about the risks society is running in this area.
That in itself is quite a scary thought.
Some work on rats was carried out in Japan and reported in 2001 and 2002. Male rats were fed parabens over a period of 8 weeks. At the end of the study it was found that their reproductive organs did show some abnormalities. The levels of parabens used were very high and the effects found were fairly small. But the study was very short. What is the significance of this? I have to say that it is far from clear that it means anything at all. But you could conclude that the results could be consistent with parabens being a long term low level risk.
There have been other studies as well, but I don’t think any of them changes the conclusion. There simply isn’t enough data to be sure one way or the other. The EU’s scientific committee did a very thorough review of the data in 2005. Their conclusion was frankly a bit Delphic. There were causes for concern and more data was needed, but nothing that justified lowering the acceptable levels.
The case against parabens is weak, but has not yet been answered.
